Cellular Senescence in Non-Small Cell Lung Cancer

Huangkai Zhu; Jiaen Sun; Chong Zhang; Pei Li; Chuntao Tan; Minglei Yang; Guofang Zhao

doi:10.31083/j.fbl2812357

Cellular Senescence in Non-Small Cell Lung Cancer

Front Biosci (Landmark Ed). 2023 Dec 28;28(12):357. doi: 10.31083/j.fbl2812357.

Authors

Huangkai Zhu¹, Jiaen Sun², Chong Zhang², Pei Li¹, Chuntao Tan³, Minglei Yang¹, Guofang Zhao¹

Affiliations

¹ Department of Thoracic Surgery, Ningbo No.2 Hospital, 315010 Ningbo, Zhejiang, China.
² Health Science Center, Ningbo University, 315211 Ningbo, Zhejiang, China.
³ Department of Cardiac and Vascular Surgery, Ningbo No.2 Hospital, 315010 Ningbo, Zhejiang, China.

PMID: 38179738
DOI: 10.31083/j.fbl2812357

Abstract

Lung cancer has the highest mortality rate amongst all malignancies worldwide, and is the second-highest incidence of cancer in women. Non-small cell lung cancer (NSCLC) is responsible for approximately 80% of lung cancer cases. Recent studies indicate that cellular senescence may be a promising cancer biomarker. However, the regulation of cellular senescence and its underlying mechanisms in NSCLC are not yet fully understood. Here, we present a comprehensive analysis of the genes linked to cellular senescence in NSCLC. We also describe the secretory phenotype associated with NSCLC and examine its immune profile and prognostic potential. Our findings offer novel insights into the development of effective NSCLC treatments.

Keywords: cellular senescence; non-small cell lung cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Non-Small-Cell Lung* / genetics
Carcinoma, Non-Small-Cell Lung* / pathology
Cellular Senescence / genetics
Female
Humans
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology

Abstract

Publication types

MeSH terms

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