Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction: Impact on urinary morbidity and mitigation strategies

Constance Huck; Vérane Achard; Priyamvada Maitre; Vedang Murthy; Thomas Zilli

doi:10.1016/j.ctro.2023.100709

Stereotactic body radiation therapy for prostate cancer after surgical treatment of prostatic obstruction: Impact on urinary morbidity and mitigation strategies

Clin Transl Radiat Oncol. 2023 Dec 10:45:100709. doi: 10.1016/j.ctro.2023.100709. eCollection 2024 Mar.

Authors

Constance Huck¹, Vérane Achard^{2

3}, Priyamvada Maitre⁴, Vedang Murthy⁴, Thomas Zilli^{3

5

6}

Affiliations

¹ Division of Radiation Oncology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
² Division of Radiation Oncology, Fribourg Cantonal Hospital, Fribourg, Switzerland.
³ Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁴ Tata Memorial Hospital and Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Homi Bhabha National Institute (HBNI), Mumbai, India.
⁵ Division of Radiation Oncology, Oncology Institute of Southern Switzerland (IOSI), EOC, Bellinzona, Switzerland.
⁶ Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.

Abstract

In the past decade, stereotactic body radiation therapy (SBRT) has emerged as a valid treatment option for patients with localized prostate cancer. Despite the promising results of ultra-hypofractionation in terms of tolerance and disease control, the toxicity profile of SBRT for prostate cancer patients with a history of surgical treatment of benign prostate hyperplasia is still underreported. Here we present an overview of the available data on urinary morbidity for prostate cancer patients treated with SBRT after prior surgical treatments for benign prostate hyperplasia. Technical improvements useful to minimize toxicity and possible treatments for radiation-induced urethritis are discussed.

Keywords: Adenomectomy; Prostate cancer; Radiotherapy; Stereotactic body radiation therapy; Toxicity; Transurethral resection.