A localized pallidal physiomarker in Meige syndrome

Bo Zhang; Hong Tian; Yanbing Yu; Xueke Zhen; Li Zhang; Yue Yuan; Liang Wang

doi:10.3389/fneur.2023.1286634

A localized pallidal physiomarker in Meige syndrome

Front Neurol. 2023 Dec 21:14:1286634. doi: 10.3389/fneur.2023.1286634. eCollection 2023.

Authors

Bo Zhang^{1

2}, Hong Tian³, Yanbing Yu³, Xueke Zhen³, Li Zhang³, Yue Yuan³, Liang Wang^{4

5}

Affiliations

¹ Key Laboratory of Brain Science, Zunyi Medical University, Zunyi, China.
² Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyi, China.
³ Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China.
⁴ CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
⁵ Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.

Abstract

Objectives: Oscillatory patterns in local field potentials (LFPs) have been recognized as disease-specific physiomarkers, particularly in the context of Parkinson's disease and cervical dystonia. This characteristic oscillatory feature is currently employed in adaptive deep brain stimulation (aDBS). However, for other types of dystonia, especially Meige syndrome, a distinct physiomarker of this nature is yet to be identified.

Methods: Local field potentials were recorded during microelectrode-guided deep brain stimulation surgery from 28 patients with primary Meige syndrome. Before surgery, the severity of patients' motor syndrome were assessed using the Burke-Fahn-Marsden Dystonia Rating Scale-Motor (BFMDRS-M). An instantaneous oscillation detection method was employed to identify true narrowband oscillations. Subsequently, a linear mixed effects model was utilized to examine the relationship between oscillatory activities (including power amplitude and burst duration) and symptom severity.

Results: The focal peaks of "oscillatory activities" detected were predominantly concentrated in the narrow theta band (4-8 Hz), constituting 81.5% of the total detected oscillations in all recording sites near active DBS contacts in the globus pallidus internus (GPi). The linear mixed effects model revealed a positive correlation between the theta burst duration and the severity of preoperative motor impairment, but no correlation with postoperative motor scores. Additionally, there was no significant lateralization effect observed between the left and right GPi.

Conclusion: Our findings suggest that the exaggerated narrowband theta activity (mainly the burst duration) in the GPi is predictive of dystonia symptom severity and may be used as a physiomarker for optimized DBS target during surgery and adaptive DBS for the treatment of Meige syndrome.

Keywords: Meige syndrome; deep brain stimulation; globus pallidus internus; local field potentials; theta oscillations.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by the National Natural Science Foundation of China (32020103009), the STI2030-Major Projects (2022ZD0205000, 2021ZD0204300), Guizhou Science and Technology Plan Project (Qian Kehe Basic-ZK[2021] General 422), Guizhou Science and Technology Plan Project (Qian Kehe platform talents [2017]5733-082), National High Level Hospital Clinical Research Funding (2023-NHLHCRF-YYPP-TS-05).