Aim: The study aimed to develop and evaluate an aquasome drug-delivery system for controlled drug delivery of cefprozil monohydrate. Materials & methods: Aquasomes were prepared by the spinal method with a calcium phosphate core, sugar-coated using cellobiose and drug-loaded by adsorption. The formulations were characterized for size, morphology and drug release. An antibacterial study was conducted for Gram-positive and -negative bacteria. Results: It showed particle size of 2791.9 nm, zeta potential of -0.3 mV with good stability, and 99.08% of drug loading and drug release were controlled and prolonged, achieving 56% within 8 h and possessing potential for 100% release beyond 12 h. Conclusion: An aquasome drug-delivery system was developed for novel controlled drug delivery for pharmaceutical antibiotic therapeutics.
Keywords: antibiotics; aquasomes; cefprozil monohydrate; nanocarrier; nanoformulation; sustained therapeutic drug delivery.
We made tiny sponge-like balls carrying a medicine called cefprozil monohydrate. We wanted to determine whether these sponge-like balls could effectively carry medicine, release it inside the body when someone is sick and fight germs. We prove that these sponge-like balls release the medicine slowly for hours. These sponge-like balls could potentially be used to deliver medication more effectively to people better to get rid of skin infections.