Electro-oxidative quinylation of sulfides to sulfur ylides in batch and continuous flow

Xiangxing Huang; Yifei Yao; Xing Yin; Wenjing Guan; Chengcheng Yuan; Zheng Fang; Hong Qin; Chengkou Liu; Kai Guo

doi:10.1016/j.isci.2023.108605

Electro-oxidative quinylation of sulfides to sulfur ylides in batch and continuous flow

iScience. 2023 Dec 1;27(1):108605. doi: 10.1016/j.isci.2023.108605. eCollection 2024 Jan 19.

Authors

Xiangxing Huang¹, Yifei Yao¹, Xing Yin², Wenjing Guan¹, Chengcheng Yuan¹, Zheng Fang¹, Hong Qin¹, Chengkou Liu¹, Kai Guo^{1

3}

Affiliations

¹ College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
² Intervention Therapy Department, General Hospital of Eastern Theater Command, Nanjing 222042, China.
³ State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China.

Abstract

An unprecedented strategy for preparing a series of sulfur ylides through electro-oxidative quinylation of sulfides in batch and continuous flow has been developed. Good to excellent yields were obtained with excellent functional group compatibility and good concentration tolerance under exogenous oxidant- and transition metal-free conditions. Advantageously, this electrosynthesis methodology was scalable with higher daily production and steady production was achieved attributing to the use of micro-flow cells.

Keywords: Chemistry; Continuum mechanics; Electrochemistry.