Unusual cutaneous adverse reaction to an erectile dysfunction drug: A case report

Ivânia Soares; Inês P Amaral; Madalena P Correia; Paulo Filipe

doi:10.1016/j.eucr.2023.102637

Unusual cutaneous adverse reaction to an erectile dysfunction drug: A case report

Urol Case Rep. 2023 Dec 9:52:102637. doi: 10.1016/j.eucr.2023.102637. eCollection 2024 Jan.

Authors

Ivânia Soares¹, Inês P Amaral¹, Madalena P Correia¹, Paulo Filipe^{1

2}

Affiliations

¹ Department of Dermatology, Hospital de Santa Maria, Avenida Professor Egas Moniz MB, 1649-028, Lisboa, Portugal.
² Dermatology Clinic, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz MB, 1649-028, Lisboa, Portugal.

Abstract

We presents an unique and significant case of Acute Generalized Exanthematous Pustulosis (AGEP) associated with the use of tadalafil, a phosphodiesterase type 5 inhibitor for erectile dysfunction. AGEP, typically linked to antibiotics and antiepileptics, had not been previously reported with tadaladil in the MEDLINE database. The case involved a 40-year-old male who developed an erythematous rash, fever and sterile pustules after starting tadalafil. A skin biopsy confirmed AGEP. Discontinuation of the drug and treatment with prednsiolone cleared the dermatosis. This case emphasizes the need for awareness among healthcare providers regarding this potential adverse reaction, considering the growing use of tadalafil.

Keywords: AGEP; Cutaneous adverse reaction; Tadalafil.

Publication types

Case Reports