Harel-Yoon syndrome caused by a novel variant in ATAD3A: A case report

Shuning Zhang; Luyao Lin; Yuelin Li; Chanjuan Peng; Yan Lin; Yongle Liu; Liyu Liang; Jiyu Huang; Qinmei Xie; Meijun Yang; Hui Zhu

doi:10.1016/j.heliyon.2023.e23669

Harel-Yoon syndrome caused by a novel variant in ATAD3A: A case report

Heliyon. 2023 Dec 12;10(1):e23669. doi: 10.1016/j.heliyon.2023.e23669. eCollection 2024 Jan 15.

Authors

Shuning Zhang^{1

2}, Luyao Lin¹, Yuelin Li¹, Chanjuan Peng¹, Yan Lin^{1

2}, Yongle Liu^{1

2}, Liyu Liang^{1

2}, Jiyu Huang^{1

2}, Qinmei Xie^{1

2}, Meijun Yang^{1

2}, Hui Zhu^{1

2}

Affiliations

¹ Department of NICU, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, 350001, PR China.
² Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou, Fujian, 350001, PR China.

Abstract

Objectives: To describe the clinical feature of a very recently identified phenotype associated with ATAD3A variation.

Methods: A neonate with Harel-Yoon syndrome was identified. We describe the proband's clinical and radiological features. The affected newborn and her parents underwent whole-exome sequencing and PCR-Sanger sequencing.

Results: Previously reported clinical manifestations were rare in the neonatal period, including unmanageable seizures necessitating the use of multiple drugs, congenital laryngeal stridor, hypotonia, challenges with feeding, corneal opacity, and subsequent demise due to respiratory failure. Molecular investigations have unveiled the presence of a newly identified heterozygous single-base substitution (c.1517A > C; p.Q506P) within the ATAD3A gene.

Discussion: This study unveils a novel single-base substitution, thereby expanding the mutation spectrum associated with ATAD3A. Furthermore, the clinical characteristics exhibited during the neonatal phase are comprehensively described, potentially facilitating improved clinical recognition of ATAD3A-associated HAYOS.

Keywords: ATAD3A; Harel-Yoon syndrome; Neonate; Seizure.

Publication types

Case Reports