Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients

Yanbin Shi; Song Wu; Xiaolin Zhang; Yangbo Cao; Lina Zhang

doi:10.1016/j.heliyon.2023.e23499

Lipid metabolism-derived FAAH is a sensitive marker for the prognosis and immunotherapy of osteosarcoma patients

Heliyon. 2023 Dec 9;10(1):e23499. doi: 10.1016/j.heliyon.2023.e23499. eCollection 2024 Jan 15.

Authors

Yanbin Shi¹, Song Wu¹, Xiaolin Zhang², Yangbo Cao¹, Lina Zhang³

Affiliations

¹ Department of Orthopaedics, The 3rd Xiangya Hospital, Central South University, Changsha, China.
² The 3rd Xiangya Hospital, Central South University, Changsha, China.
³ Hunan Provincial People's Hospital, Changsha, China.

Abstract

Lipid metabolism in cancer refers to the alterations in how cancer cells process and utilize lipids, a type of fat molecule. It was investigated how lipid metabolism relates to osteosarcoma. Genes relevant to lipid metabolism were gathered to create lipid metabolism-associated clusters and locate the dangerous marker. We investigated FAAH's prognostic significance, route annotation, immunotherapy response, and medication prediction. Besides, FAAH is proven to be a potent, dangerous marker that may promote growth and migration and inhibit the apoptosis of osteosarcoma. FAAH exhibits higher expression levels in tumor tissues as compared to normal tissues. In conclusion, FAAH is identified in this work as a potentially dangerous gene and immunotherapy determinant. This study requires more investigation to determine how FAAH influences the immune response in osteosarcoma.