Lincosamide Antibiotics: Structure, Activity, and Biosynthesis

Chembiochem. 2024 Mar 15;25(6):e202300840. doi: 10.1002/cbic.202300840. Epub 2024 Jan 15.

Abstract

Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently, lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to their unique structures and remarkable biological activities, derivatizations of lincosamides via semi-synthesis and biosynthetic studies have been reported. This review summarizes the structures and biological activities of lincosamides, and the recent studies of lincosamide biosynthetic enzymes.

Keywords: Biosynthesis; Lincosamides; Structure-activity relationship; Structure-function analysis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Lincomycin* / chemistry
  • Lincosamides / chemistry
  • Lincosamides / pharmacology
  • Macrolides

Substances

  • Anti-Bacterial Agents
  • Lincosamides
  • Lincomycin
  • Macrolides