An ATM D-compartmentalization in DNA damage response

Anjali Prasad; Arun Kanakkanthara

doi:10.1016/j.tcb.2023.12.003

An ATM D-compartmentalization in DNA damage response

Trends Cell Biol. 2024 Mar;34(3):173-175. doi: 10.1016/j.tcb.2023.12.003. Epub 2023 Dec 29.

Authors

Anjali Prasad¹, Arun Kanakkanthara²

Affiliations

¹ Department of Oncology, Mayo Clinic, Rochester, MN, USA.
² Department of Oncology, Mayo Clinic, Rochester, MN, USA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Electronic address: Kanakkanthara.Arun@mayo.edu.

PMID: 38160123
PMCID: PMC10939911 (available on 2025-03-01)
DOI: 10.1016/j.tcb.2023.12.003

Abstract

How chromatin configuration impacts DNA repair is an emerging question. A recent study by Arnould et al. shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.

Keywords: ATM; D compartment; DNA damage response; DNA repair; chromatin compartmentalization; genome integrity.

MeSH terms

Ataxia Telangiectasia Mutated Proteins / genetics
Ataxia Telangiectasia Mutated Proteins / metabolism
Chromatin*
DNA Breaks, Double-Stranded
DNA Damage
DNA Repair*
Humans

Substances

Ataxia Telangiectasia Mutated Proteins
Chromatin
ATM protein, human

Grants and funding

R37 CA261854/CA/NCI NIH HHS/United States