Ultrasound-dependent kinetics of bone mineralization

Julia R Higdon; William L Spooner; Jonghoon Kang

doi:10.1016/j.bone.2023.116999

Ultrasound-dependent kinetics of bone mineralization

Bone. 2024 Mar:180:116999. doi: 10.1016/j.bone.2023.116999. Epub 2023 Dec 27.

Authors

Julia R Higdon¹, William L Spooner², Jonghoon Kang³

Affiliations

¹ Department of Biology, Valdosta State University, Valdosta, GA 31698, USA.
² Department of Applied Mathematics and Physics, Valdosta State University, Valdosta, GA 31698, USA.
³ Department of Biology, Valdosta State University, Valdosta, GA 31698, USA. Electronic address: jkang@valdosta.edu.

PMID: 38158169
DOI: 10.1016/j.bone.2023.116999

Abstract

Bone Mineral Density (BMD) is an important parameter in the development of orthopedic fracture-healing methods. A recent article (Inoue, S., et al. Bone. 2023, 177, 116916) investigated the use of higher intensity ultrasound to promote murine bone formation by measuring BMD levels. In this work, we present the numerical values of BMD, which show sigmoid kinetics and hyperbolic asymptotic increase with the application of higher intensity ultrasound. Our analysis may provide a foundation for the understanding and application of ultrasound to the human body.

Keywords: Bone mineral density; Fracture; Nonlinear regression; Ultrasound.

Publication types

Letter
Comment

MeSH terms

Animals
Bone Density*
Bone and Bones / diagnostic imaging
Calcification, Physiologic*
Humans
Mice
Osteogenesis
Ultrasonography