Healthy Adult Left and Right Ventricular Torsion and Torsion Rates With MR-Feature Tracking

Zhen Zhang; Gengxiao Li; Yiyuan Gao; Shanshan Zhou; Jianan Xie; Shurong Liu; Zhiwei Zhao; Chengcheng Zhu; Karen Ordovas; Gerald M Pohost; Kai Sun; Kuncheng Li

doi:10.1002/jmri.29201

Healthy Adult Left and Right Ventricular Torsion and Torsion Rates With MR-Feature Tracking

J Magn Reson Imaging. 2023 Dec 29. doi: 10.1002/jmri.29201. Online ahead of print.

Authors

Zhen Zhang¹, Gengxiao Li², Yiyuan Gao³, Shanshan Zhou¹, Jianan Xie¹, Shurong Liu¹, Zhiwei Zhao⁴, Chengcheng Zhu⁵, Karen Ordovas⁵, Gerald M Pohost^{4

6}, Kai Sun¹, Kuncheng Li^{1

4

7}

Affiliations

¹ Department of Radiology, Medical imaging research institute of Longgang, the Third People's Hospital of Longgang District, Shenzhen, China.
² Department of Radiology, Shenzhen Second People's Hospital, Shenzhen, China.
³ The First School of Clinical Medicine of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
⁴ Zhouxin Medical Imaging and Health Screening Center, Xiamen, Fujian, China.
⁵ Department of Radiology, University of Washington, Seattle, Washington, USA.
⁶ Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
⁷ Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

PMID: 38156373
DOI: 10.1002/jmri.29201

Abstract

Background: The clinical value of myocardial torsion quantification in prognostic assessment and risk stratification of various cardiovascular diseases is gradually being recognized. However, normal values of left and right ventricular (LV and RV) torsion and torsion rates (TRs) have not been fully determined, and their correlation with age and gender has not been well studied.

Purpose: To establish normal ranges of biventricular torsion, peak systolic and diastolic TRs using magnetic resonance feature tracking (MR-FT) technique based on a large sample of healthy adults, and further investigate their relationship with age and gender.

Study type: Retrospective.

Population: 566 Healthy adults (312 males, aged 43 ± 10 years; 254 females, aged 43 ± 11 years).

Field strength/sequence: 1.5T/gradient echo.

Assessment: Biventricular torsion, peak systolic, and diastolic TRs.

Statistical tests: Shapiro-Wilk test, Student's t-test, Mann-Whitney-U test, linear regression, intraclass correlation coefficient, Bland-Altman analysis. Differences were regarded as statistically significant at P < 0.05.

Results: Women demonstrated greater magnitudes of left ventricle (LV) torsion (1.23 ± 0.44 vs. 1.00 ± 0.42°/cm), peak systolic TR (9.69 ± 3.70 vs. 8.27 ± 3.73°/cm*sec), peak diastolic TR (-7.78 ± 2.82 vs. -6.06 ± 2.44°/cm*sec), and RV torsion (2.20 ± 1.23 vs. 1.65 ± 1.11°/cm*sec), peak systolic TR (16.07 ± 8.18 vs. 12.62 ± 7.08°/cm*sec), peak diastolic TR (-15.39 ± 6.53 vs. -11.70 ± 6.03°/cm*sec). For both genders, the magnitudes of LV and RV torsion, peak systolic, and diastolic TRs increased linearly with age. All the measurements of biventricular torsion, peak systolic and diastolic TRs achieved good to excellent intraobserver and interobserver reproducibility, with all intraclass correlation coefficients >0.70.

Data conclusion: The present study systematically provided age- and sex-stratified reference values for LV and RV torsion and TRs using MR-FT technique. Women and aging are associated with greater magnitudes of biventricular torsion, peak systolic, and diastolic TRs.

Level of evidence: 3 TECHNICAL EFFICACY: Stage 2.

Keywords: left ventricle; magnetic resonance-feature tracking; normal values; right ventricle; torsion; torsion rate.

Grants and funding

LGKCYLWS2022038/Shenzhen Longgang District Science and Technology Innovation Special Fund