Potential role of N6-methyladenosine modification in the development of Parkinson's disease

Jiale Zhou; Yang Han; Ruizhe Hou

doi:10.3389/fcell.2023.1321995

Potential role of N6-methyladenosine modification in the development of Parkinson's disease

Front Cell Dev Biol. 2023 Dec 13:11:1321995. doi: 10.3389/fcell.2023.1321995. eCollection 2023.

Authors

Jiale Zhou¹, Yang Han^{1

2}, Ruizhe Hou³

Affiliations

¹ Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
² Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China.
³ Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Abstract

N6-methyladenosine (m6A) represents the most abundant modification of messenger RNA (mRNA) and is regulated by methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers). A dynamic modification process is implicated in nearly every critical stage of RNA metabolism, including mRNA stability, transcription, translation, splicing, nuclear export, and decay. Notably, m6A methylation is significantly enriched in the brain and has recently been shown to be associated with neurodevelopmental disorders and the development of Parkinson's disease (PD). In this review, we summarize the proteins involved in the process of m6A modification and elucidate the emerging role of m6A modification in PD, which could illuminate alternative strategies for the prevention and treatment of PD.

Keywords: N6-methylAdenosine (m6A); Neurological disease; RNA methylation; epigenetics; methyltransferase; neurodevelopment.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was financially supported by the National Natural Science Foundation of China (No. 32200466).