Pan-cancer analysis identifies EMC6 as a potential target for lung adenocarcinoma

Xin Zhou; Bowen Xiao; Manman Jiang; Jun Rui

doi:10.1016/j.isci.2023.108648

Pan-cancer analysis identifies EMC6 as a potential target for lung adenocarcinoma

iScience. 2023 Dec 8;27(1):108648. doi: 10.1016/j.isci.2023.108648. eCollection 2024 Jan 19.

Authors

Xin Zhou¹, Bowen Xiao², Manman Jiang³, Jun Rui⁴

Affiliations

¹ Department of Urology, The Wuxi No.2 People's Hospital, Wuxi, China.
² Department of Interventional Vascular Department, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
³ Suzhou Center for Disease Control, Suzhou, China.
⁴ Department of Chest, The Wuxi No.2 People's Hospital, Wuxi, China.

Abstract

Endoplasmic reticulum membrane protein complex subunit 6 (EMC6) plays an important function in both physiological and pathological states of cells. Nevertheless, there are few studies focused on the role of EMC6 in tumors. At first, we performed a series of bioinformatics analyses on 33 kinds of cancers, including differential expression analysis, tumor mutational burden analysis, prognostic analysis, and clinicopathological staging analysis. Then, we corroborated the important role of EMC6 in lung cancer by cytological and in vivo experiments. We found that the reduction of EMC6 expression did effectively inhibit the proliferation, invasion, and metastasis of A549. Finally, EMC6 is indeed involved in the regulation of ferroptosis, cuproptosis, and immune response in LUAD. In a word, our study not only comprehensively analyzed the functional mechanisms of EMC6 in all cancers but also validated the regulatory role of EMC6 in lung cancer for the first time.

Keywords: Bioinformatics; Molecular biology.