Cationic nanoparticles-based approaches for immune tolerance induction in vivo

Kuirong Mao; Jialiang Wang; Qianyue Xie; Yong-Guang Yang; Song Shen; Tianmeng Sun; Jun Wang

doi:10.1016/j.jconrel.2023.12.044

Cationic nanoparticles-based approaches for immune tolerance induction in vivo

J Control Release. 2024 Feb:366:425-447. doi: 10.1016/j.jconrel.2023.12.044. Epub 2024 Jan 9.

Authors

Kuirong Mao¹, Jialiang Wang², Qianyue Xie³, Yong-Guang Yang¹, Song Shen⁴, Tianmeng Sun⁵, Jun Wang⁶

Affiliations

¹ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; International Center of Future Science, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China.
² Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China.
³ Huafu International Department, Affiliated High School of South China Normal University, Guangzhou, Guangdong, China.
⁴ School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, Guangdong, China.
⁵ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; International Center of Future Science, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China. Electronic address: tsun41@jlu.edu.cn.
⁶ School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, Guangdong, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, China; Key Laboratory of Biomedical Engineering of Guangdong Province, and Innovatiion Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong, China. Electronic address: mcjwang@scut.edu.cn.

PMID: 38154540
DOI: 10.1016/j.jconrel.2023.12.044

Abstract

The development of autoimmune diseases and the rejection of transplanted organs are primarily caused by an exaggerated immune response to autoantigens or graft antigens. Achieving immune tolerance is crucial for the effective treatment of these conditions. However, traditional therapies often have limited therapeutic efficacy and can result in systemic toxic effects. The emergence of nanomedicine offers a promising avenue for addressing immune-related diseases. Among the various nanoparticle formulations, cationic nanoparticles have demonstrated significant potential in inducing immune tolerance. In this review, we provide an overview of the underlying mechanism of autoimmune disease and organ transplantation rejection. We then highlight the recent advancements and advantages of utilizing cationic nanoparticles for inducing immune tolerance in the treatment of autoimmune diseases and the prevention of transplant rejection.

Keywords: Autoimmunity; Cationic nanoparticles; Drug delivery; Immune tolerance; Transplant rejection.

Publication types

Review

MeSH terms

Autoantigens
Autoimmune Diseases* / therapy
Cations
Humans
Immune Tolerance
Nanoparticles*

Substances

Autoantigens
Cations