The renal damage and mechanisms relevant to antitumoral drugs

Jiyu Tang; Nan Yang; Shujun Pan; Peiyao Ren; Maosheng Chen; Juan Jin; Qiang He; Yuqun Zeng

doi:10.3389/fonc.2023.1331671

The renal damage and mechanisms relevant to antitumoral drugs

Front Oncol. 2023 Dec 12:13:1331671. doi: 10.3389/fonc.2023.1331671. eCollection 2023.

Authors

Jiyu Tang^#^{1

2}, Nan Yang^#^{2

3}, Shujun Pan⁴, Peiyao Ren⁵, Maosheng Chen², Juan Jin⁶, Qiang He⁶, Yuqun Zeng²

Affiliations

¹ The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
² Department of Nephrology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China.
³ Jinzhou Medical University, Graduate School of Clinical Medicine, Jinzhou, China.
⁴ School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
⁵ School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
⁶ Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.

^# Contributed equally.

Abstract

Over the past few decades, significant progress has been made in the development of drugs to combat cancer. It is unfortunate that these drugs can also lead to various kidney injuries and imbalances in electrolyte levels. Nephrotoxicity caused by chemotherapy drugs can impact different parts of the kidneys, including the glomeruli, renal tubules, interstitium, or renal microvessels. Despite the existing knowledge, our understanding of the mechanisms underlying the renal damage caused by antitumoral drugs remains incomplete. In this review, we aim to provide a comprehensive overview of the specific types of kidney injury and the mechanisms responsible for the drug-mediated renal damage, and briefly discuss possible prevention and treatment measures. Sensitive blood and urine biomarkers can provide clinicians with more information about kidney injury detection and reference value for subsequent treatment options. In addition, we emphasize that both oncologists and nephrologists have a responsibility to remain vigilant against the potential nephrotoxicity of the drugs. It's crucial for experts in both fields to collaborate in early detection, monitoring and prevention of kidney damage.

Keywords: antineoplastic drugs; early markers; mechanisms; nephrotoxicity; renal damage.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from the National Natural Scientific Foundation of China (82004116), the Zhejiang Provincial Natural Science Foundation of China (LQ20H290006), the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2023KY539), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (No. LHDMZ22H050001), the Construction of Key Projects by Zhejiang Provincial Ministry (No.WKJ-ZJ-2302), The Key Project of Scientific Research Foundation of Chinese Medicine (2022ZZ002), the “Pioneer” and “Leading Goose” R&D Program of Zhejiang (2023C03075), The Key project of Basic Scientific Research Operating Funds of Hangzhou Medical College (KYZD202002), the Medical Science and Technology Project of Zhejiang Province (No.2019320552).