The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Patrick Nylund; Berta Garrido-Zabala; Antonia Kalushkova; Helena Jernberg Wiklund

doi:10.3389/fonc.2023.1303677

The complex nature of lncRNA-mediated chromatin dynamics in multiple myeloma

Front Oncol. 2023 Dec 11:13:1303677. doi: 10.3389/fonc.2023.1303677. eCollection 2023.

Authors

Patrick Nylund^#¹, Berta Garrido-Zabala^#¹, Antonia Kalushkova¹, Helena Jernberg Wiklund¹

Affiliation

¹ Science for Life Laboratory, Department of Immunology, Genetic and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.

^# Contributed equally.

Abstract

Extensive genome-wide sequencing efforts have unveiled the intricate regulatory potential of long non-protein coding RNAs (lncRNAs) within the domain of haematological malignancies. Notably, lncRNAs have been found to directly modulate chromatin architecture, thereby impacting gene expression and disease progression by interacting with DNA, RNA, and proteins in a tissue- or condition-specific manner. Furthermore, recent studies have highlighted the intricate epigenetic control of lncRNAs in cancer. Consequently, this provides a rationale to explore the possibility of therapeutically targeting lncRNAs themselves or the epigenetic mechanisms that govern their activity. Within the scope of this review, we will assess the current state of knowledge regarding the epigenetic regulation of lncRNAs and how, in turn, lncRNAs contribute to chromatin remodelling in the context of multiple myeloma.

Keywords: RNA modifications; chromatin regulation; epigenetics; haematological malignancies; lncRNA; multiple myeloma.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The project was supported by grants from the Swedish Research Council (K2019-64X-20102-13-3/KDB 1335/17) and the Swedish Cancer Society (CAN 2016/458, 200727 PjVSF).