The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia

Mengting Yang; Yanhui Tang; Peng Zhu; Haiquan Lu; Xiaohong Wan; Qulian Guo; Lan Xiao; Chunyan Liu; Ling Guo; Wenjun Liu; You Yang

doi:10.1007/s00277-023-05595-7

The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia

Ann Hematol. 2023 Dec 27. doi: 10.1007/s00277-023-05595-7. Online ahead of print.

Authors

Mengting Yang^#^{1

2}, Yanhui Tang^#^{1

2}, Peng Zhu^#³, Haiquan Lu⁴, Xiaohong Wan^{1

2}, Qulian Guo^{1

2}, Lan Xiao^{1

2}, Chunyan Liu^{1

2}, Ling Guo^{1

2}, Wenjun Liu^{5

6}, You Yang^{7

8

9}

Affiliations

¹ Department of Paediatrics (Children Haematological Oncology), Birth Defects and Childhood Haematological Oncology Laboratory, Sichuan Clinical Research Centre for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
² Department of Paediatrics, Southwest Medical University, Luzhou, Sichuan, China.
³ School of Pharmacy, Wannan Medical College, Wuhu, 241000, People's Republic of China.
⁴ The Second Hospital, Centre for Reproductive Medicine, Advanced Medical Research Institute, Key Laboratory for Experimental Teratology of the Ministry of Education, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
⁵ Department of Paediatrics (Children Haematological Oncology), Birth Defects and Childhood Haematological Oncology Laboratory, Sichuan Clinical Research Centre for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. wenjun_liu@swmu.edu.cn.
⁶ Department of Paediatrics, Southwest Medical University, Luzhou, Sichuan, China. wenjun_liu@swmu.edu.cn.
⁷ Department of Paediatrics (Children Haematological Oncology), Birth Defects and Childhood Haematological Oncology Laboratory, Sichuan Clinical Research Centre for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China. youyang091@swmu.edu.cn.
⁸ Department of Paediatrics, Southwest Medical University, Luzhou, Sichuan, China. youyang091@swmu.edu.cn.
⁹ The Second Hospital, Centre for Reproductive Medicine, Advanced Medical Research Institute, Key Laboratory for Experimental Teratology of the Ministry of Education, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. youyang091@swmu.edu.cn.

^# Contributed equally.

PMID: 38148344
DOI: 10.1007/s00277-023-05595-7

Abstract

The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically exhibit an intermediate prognosis. Furthermore, minimal residual disease has unsatisfactory prognostic value in E2A-PBX1 B-cell acute lymphoblastic leukaemia. However, the mechanism of E2A-PBX1 in the occurrence and progression of B-cell acute lymphoblastic leukaemia is not well understood. Here, we mainly review the roles of E2A and PBX1 in the differentiation and development of B lymphocytes, the mechanism of E2A-PBX1 gene fusion in B-cell acute lymphoblastic leukaemia, and the potential therapeutic approaches.

Keywords: B-ALL; B-cell differentiation; E2A; E2A-PBX1; PBX1.

Publication types

Review

Grants and funding

2023M732926/Postdoctoral Research Foundation of China