Temperature fluctuation and acute myocardial infarction in Beijing: an extended analysis of temperature ranges and differences

Siqi Tang; Jia Fu; Yanbo Liu; Yakun Zhao; Yuxiong Chen; Yitao Han; Xinlong Zhao; Yijie Liu; Xiaofeng Jin; Zhongjie Fan

doi:10.3389/fpubh.2023.1287821

Temperature fluctuation and acute myocardial infarction in Beijing: an extended analysis of temperature ranges and differences

Front Public Health. 2023 Dec 11:11:1287821. doi: 10.3389/fpubh.2023.1287821. eCollection 2023.

Authors

Siqi Tang^#¹, Jia Fu^#², Yanbo Liu³, Yakun Zhao¹, Yuxiong Chen¹, Yitao Han¹, Xinlong Zhao¹, Yijie Liu¹, Xiaofeng Jin¹, Zhongjie Fan¹

Affiliations

¹ Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
² Department of Cardiology, Fuwai Yunnan Cardiovascular Hospital, Kunming, Yunnan, China.
³ Department of International Medical Services, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

^# Contributed equally.

Abstract

Purpose: Few studies examined the relationship between temperature fluctuation metrics and acute myocardial infarction (AMI) hospitalizations within a single cohort. We aimed to expand knowledge on two basic measures: temperature range and difference.

Methods: We conducted a time-series analysis on the correlations between temperature range (TR), daily mean temperature differences (DTDmean), and daily mean-maximum/minimum temperature differences (TDmax/min) and AMI hospitalizations, using data between 2013 and 2016 in Beijing, China. The effects of TR_n and DTDmean_n over n-day intervals were compared, respectively. Subgroup analysis by age and sex was performed.

Results: A total of 81,029 AMI hospitalizations were included. TR₁, TDmax, and TDmin were associated with AMI in J-shaped patterns. DTDmean₁ was related to AMI in a U-shaped pattern. These correlations weakened for TR and DTDmean with longer exposure intervals. Extremely low (1st percentile) and high (5°C) DTDmean₁ generated cumulative relative risk (CRR) of 2.73 (95% CI: 1.56-4.79) and 2.15 (95% CI: 1.54-3.01). Extremely high TR₁, TDmax, and TDmin (99th percentile) correlated with CRR of 2.00 (95% CI: 1.73-2.85), 1.71 (95% CI: 1.40-2.09), and 2.73 (95% CI: 2.04-3.66), respectively. Those aged 20-64 had higher risks with large TR₁, TDmax, and TDmin, while older individuals were more affected by negative DTDmean₁. DTDmean₁ was associated with a higher AMI risk in females.

Conclusion: Temperature fluctuations were linked to increased AMI hospitalizations, with low-temperature extremes having a more pronounced effect. Females and the older adult were more susceptible to daily mean temperature variations, while younger individuals were more affected by larger temperature ranges.

Keywords: acute myocardial infarction; age; sex; temperature difference; temperature range.

MeSH terms

Aged
Beijing / epidemiology
Female
Hospitalization*
Hot Temperature
Humans
Myocardial Infarction* / epidemiology
Temperature

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was funded by National High Level Hospital Clinical Research Funding (2022-PUMCH-C-024, 2022-PUMCH-B-030, 2022-PUMCH-A-241), National Natural Science Foundation (12126602 and 91643208) , Chinese Academy of Medical Sciences Initiative for Innovative Medicine (2017-I2M-2-001), Yunnan Provincial Clinical Research Center for Cardiovascular Diseases (202302AA310045), and Fuwai Yunnan Cardiovascular Hospital for Cardiovascular Diseases (2019YFKT-09).