Objectives: To compare the effects of 2 Hz continuous wave and 2 Hz/100 Hz dilatational wave setting in electroacupuncture(EA) on ovulation frequency, hormone levels, body fat parameters, quality of life and depression-anxiety level in polycystic ovary syndrome (PCOS) patients with abdominal obesity.
Methods: PCOS patients with abdominal obesity were randomly divided into low-frequency group (n=29) and dilatational wave group (n=29). Patients in both groups were treated with "Tongtiaodaimai" (regulating Dai Meridian) acupuncture therapy, and EA was applied to bilateral Daimai (GB26), Tianshu (ST25), Shenshu (BL23) and Ciliao (BL32). The low-frequency group received EA using a continuous wave at a frequency of 2 Hz, while the dilatational wave group received dilatational wave at a frequency of 2 Hz/100 Hz. Both groups received treatment for 30 min each time, 3 times per week for 12 consecutive weeks. Ovulation frequency was calculated according to the ovulation cycle. The contents of serum anti-Mullerian hormone (AMH) and sex hormone binding globulin (SHBG) were detected with electrochemiluminescence method. Body weight (BW) and waist circumference (WC) were measured, and body mass index (BMI) and waist-height ratio (WHtR) were calculated. PCOS questionnaire (Chi-PCOSQ), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were evaluated.
Results: Compared with before treatment, both the low-frequency group and the dilatational wave group showed an increase in ovulation frequency (P<0.01, P<0.05), and a decrease in BW, BMI, WC, WHtR, and SDS score (P<0.01, P<0.05)；the dilatational wave group showed decreased serum AMH contents (P<0.05) and increased serum SHBG contents (P<0.05), the scores related to acne, fatigue, and dysmenorrhea in the Chi-PCOSQ increased (P<0.01, P<0.05). Compared with the low-frequency group, the dilatational wave group showed a reduction (P<0.05) in WC after treatment.
Conclusions: 2 Hz/100 Hz dilatational wave EA is equally effective as 2 Hz low-frequency EA in improving ovulation frequency. In terms of reducing WC in abdominal obesity type PCOS patients, 2 Hz/100 Hz dilatational wave EA is superior to 2 Hz low-frequency EA. 2 Hz/100 Hz dilatational wave EA can decrease serum AMH, increase serum SHBG, and improve symptoms of acne, fatigue, and dysmenorrhea.
目的: 比较2 Hz连续波电针及2 Hz/100 Hz疏密波电针对腹部肥胖型多囊卵巢综合征（PCOS）患者的排卵频率、激素水平、体脂参数、生活质量及抑郁焦虑程度的作用效果差异。方法: 将腹部肥胖型PCOS患者随机分为低频组、疏密波组各29例。低频组采用通调带脉针刺法，电针采用连续波，频率2 Hz；疏密波组采用同种针刺方法，电针采用疏密波，频率2 Hz/100 Hz。两组均每次治疗30 min，每周治疗3次，连续12周。计算患者排卵频率，采用电化学发光法检测血清抗缪勒氏管激素（AMH）和性激素结合球蛋白（SHBG）含量，测量体质量（BW）和腰围（WC），计算体质量指数（BMI）和腰高比（WHtR），评定PCOS生活质量问卷（Chi-PCOSQ）、焦虑自评量表（SAS）、抑郁自评量表（SDS）评分。结果: 与治疗前比较，治疗后低频组和疏密波组排卵频率均升高（P<0.01，P<0.05），BW、BMI、WC、WHtR降低（P<0.01），SDS评分降低（P<0.01，P<0.05）；疏密波组血清AMH含量降低（P<0.05），SHBG含量升高（P<0.05），Chi-PCOSQ中关于痤疮、疲劳感及痛经的问题分数升高（P<0.01，P<0.05）。与低频组比较，疏密波组治疗后WC降低（P<0.05）。结论: 2 Hz/100 Hz疏密波电针与2 Hz低频电针在改善PCOS患者排卵频率方面疗效相当。2 Hz/100 Hz疏密波电针在降低腹部肥胖型PCOS患者WC疗效上优于2 Hz低频电针，可使血清AMH降低、SHBG升高，并改善痤疮、疲劳感及痛经症状。.
Keywords: Electroacupuncture; Frequency; Polycystic ovary syndrome; Randomized controlled trial.