Acute stress modulates hippocampal to entorhinal cortex communication

Azat Nasretdinov; David Jappy; Alina Vazetdinova; Fliza Valiullina-Rakhmatullina; Andrei Rozov

doi:10.3389/fncel.2023.1327909

Acute stress modulates hippocampal to entorhinal cortex communication

Front Cell Neurosci. 2023 Dec 7:17:1327909. doi: 10.3389/fncel.2023.1327909. eCollection 2023.

Authors

Azat Nasretdinov¹, David Jappy^{2

3}, Alina Vazetdinova^{1

2}, Fliza Valiullina-Rakhmatullina^{1

2}, Andrei Rozov^{2

4}

Affiliations

¹ Laboratory of Neurobiology, Kazan Federal University, Kazan, Russia.
² Federal Center of Brain Research and Neurotechnologies, Moscow, Russia.
³ Institute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
⁴ Department of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany.

Abstract

Feed-forward inhibition is vital in the transfer and processing of synaptic information within the hippocampal-entorhinal loop by controlling the strength and direction of excitation flow between different neuronal populations and individual neurons. While the cellular targets in the hippocampus that receive excitatory inputs from the entorhinal cortex have been well studied, and the role of feedforward inhibitory neurons has been attributed to neurogliafom cells, the cortical interneurons providing feed-forward control over receiving layer V in the entorhinal cortex remain unknown. We used sharp-wave ripple oscillations as a natural excitatory stimulus of the entorhinal cortex, driven by the hippocampus, to study the function of synaptic interactions between neurons in the deep layers of the entorhinal cortex. We discovered that CB1R-expressing interneurons in the deep layers of the entorhinal cortex constitute the major relay station that translates hippocampal excitation into efficient inhibition of cortical pyramidal cells. The impact of inhibition provided by these interneurons is under strong endocannabinoid control and can be drastically reduced either by enhanced activity of postsynaptic targets or by stress-induced elevation of cannabinoids.

Keywords: CB1R; SPW-R; endocannabinoids; feed-forward inhibition; stress.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by RSF grant 22-15-00293 (to AV, FV-R, and AR) and by the “Center of Photonics” funded by the Ministry of Science and Higher Education of the Russian Federation (contract no. 075-15-2022-293) to DJ.