Impact of Coriandrum sativum seeds extract on albino rats' testicular toxicity caused by carbendazim

Ehab Tousson; Somaya Y Shalaby; Doaa M El-Gharbawy; Mohamed A Akela; Mohamed Rabea; Eman H Kandil

doi:10.1093/toxres/tfad109

Impact of Coriandrum sativum seeds extract on albino rats' testicular toxicity caused by carbendazim

Toxicol Res (Camb). 2023 Dec 1;12(6):1152-1158. doi: 10.1093/toxres/tfad109. eCollection 2023 Dec.

Authors

Ehab Tousson¹, Somaya Y Shalaby², Doaa M El-Gharbawy³, Mohamed A Akela⁴, Mohamed Rabea², Eman H Kandil²

Affiliations

¹ Department of Zoology, Faculty of Science, Tanta University, Egypt.
² Department of Zoology, Faculty of Science, Menoufia University, Egypt.
³ Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta University, Egypt.
⁴ Department of Biology, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

PMID: 38145095
PMCID: PMC10734600 (available on 2024-12-01)
DOI: 10.1093/toxres/tfad109

Abstract

Background: A broad spectrum carbamate fungicide called carbendazim (Carb) is used to combat a number of different fungal diseases. One of the extensively utilized medicinal plants in oriental countries is Coriandrum sativum.

Aim: In the current study, the impact of C. sativum seeds extract (CSE) on albino rats' testicular toxicity caused by carbendazim was investigated.

Materials and methods: A total of 50 male albino rats were classified into 5 groups [Gp1, Control Gp; Gp2, Coriandrum Gp (CSE); Gp 3, carbendazim Gp (Carb); Gp 4, Co treated CSE with Carb (CSE + Carb); Gp 5, Post treated Carb with CSE (Carb + CSE)].

Results: Carb induced elevation in serum LH. FSH, testicular malondialdehyde (MDA), testicular nitric oxide (NO) markers and testicular injury and it reduced serum testosterone, testicular glutathione (GSH), testicular catalase and PCNA. Treatments of Carb with CSE (CSE + Carb and/or Carb + CSE) improved these parameters and reduced testicular toxicity with best results for Carb + CSE than CSE + Carb.

Conclusions: The above findings revealed that; Carb induced testicular toxicity and it supported the hypothesis that the antioxidant characteristics of one or more of CSE constituents can reduce the testicular toxicity of Carb.

Keywords: Coriandrum sativum; antioxidant; carbendazim; testis.