An update: is there a relationship between H. pylori infection and nonalcoholic fatty liver disease? why is this subject of interest?

Xingcen Chen; Ruyi Peng; Dongzi Peng; Jia Xiao; Deliang Liu; Rong Li

doi:10.3389/fcimb.2023.1282956

An update: is there a relationship between H. pylori infection and nonalcoholic fatty liver disease? why is this subject of interest?

Front Cell Infect Microbiol. 2023 Dec 8:13:1282956. doi: 10.3389/fcimb.2023.1282956. eCollection 2023.

Authors

Xingcen Chen^{1

2

3}, Ruyi Peng^{1

2

3}, Dongzi Peng^{1

2

3}, Jia Xiao^{1

2

3}, Deliang Liu^{1

2

3}, Rong Li^{1

2

3}

Affiliations

¹ Department of Gastroenterology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
² Research Center of Digestive Diseases, Central South University, Changsha, Hunan, China.
³ Clinical Research Center, Digestive Diseases of Hunan Province, Changsha, Hunan, China.

Abstract

Helicobacter pylori (H. pylori) infection is thought to impact various extragastric diseases, including nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease. Meanwhile, the pathogenesis of NAFLD needs further research, and effective treatment for this disease remains elusive. In this mini-review, we enumerate and ponder on the evidence demonstrating an association between H. pylori infection and NAFLD. Primarily, we delve into high-quality meta-analyses and clinical randomized controlled trials focusing on the association studies between the two. We also discuss clinical studies that present opposite conclusions. In addition, we propose a mechanism through which H. pylori infection aggravates NAFLD: inflammatory cytokines and adipocytokines, insulin resistance, lipid metabolism, intestinal barrier and microbiota, H. pylori outer membrane vesicles and H. pylori-infected cell-extracellular vesicles. This mini-review aims to further explore NAFLD pathogenesis and extragastric disease mechanisms caused by H. pylori infection.

Keywords: Helicobacter pylori; extragastric disease; meta-analysis; nonalcoholic fatty liver disease; pathogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines
Helicobacter Infections* / complications
Helicobacter pylori*
Humans
Insulin Resistance*
Non-alcoholic Fatty Liver Disease* / etiology

Substances

Cytokines

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Natural Science Foundation of Hunan Province under Grant 211087206069.