Development of a Highly Sensitive Electrochemical Sensor Using Sm2CuZrO6 Double Perovskite as an Electrocatalyst for Determination of Risperidone Antipsychotic Drug in Tablet Samples

Srujan Basavapura Ravikumar; Sanjay Ballur Prasanna; Nanjunda Swamy Shanthappa; Shruthi Chinnakurli Dwarakanath; Santhosh Arehalli Shivamurthy; Sandeep Shadakshari; Karthik Chimatahalli Shanthakumar; Hamad A Al-Lohedan; Muthusamy Karnan

doi:10.1021/acsomega.3c06254

Development of a Highly Sensitive Electrochemical Sensor Using Sm₂CuZrO₆ Double Perovskite as an Electrocatalyst for Determination of Risperidone Antipsychotic Drug in Tablet Samples

ACS Omega. 2023 Dec 7;8(50):47781-47790. doi: 10.1021/acsomega.3c06254. eCollection 2023 Dec 19.

Authors

Srujan Basavapura Ravikumar¹, Sanjay Ballur Prasanna², Nanjunda Swamy Shanthappa¹, Shruthi Chinnakurli Dwarakanath³, Santhosh Arehalli Shivamurthy³, Sandeep Shadakshari¹, Karthik Chimatahalli Shanthakumar¹, Hamad A Al-Lohedan⁴, Muthusamy Karnan⁵

Affiliations

¹ Department of Chemistry, SJCE, JSS Science and Technology University, Mysuru, Karnataka 570006, India.
² Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan.
³ Department of Chemistry (U.G.), N.M.K.R.V. College for Women, Bangalore, Karnataka 560011, India.
⁴ Department of Chemistry, College of Science, King Saud University, P.O. Box. 2455, Riyadh 11451, Saudi Arabia.
⁵ Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Cheonan, Chungcheongnam-do 3100, South Korea.

Abstract

In this study, the preparation of Sm₂CuZrO₆ double perovskites was carried out through the utilization of a sol-gel technique. The Sm₂CuZrO₆ displayed notable conductivity, impressive electrocatalytic activity, and rapid electron transfer. The monitoring of risperidone (RIS) in tablet samples is greatly influenced by these properties. Various techniques for structural and morphological characterization were employed to confirm the formation of Sm₂CuZrO₆. The electrochemical properties of Sm₂CuZrO₆ were assessed through utilization of cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and linear sweep voltammetry (LSV). Interestingly, the Sm₂CuZrO₆ exhibited a remarkable wide linear range of 50-500 nM, along with a detection limit of 10.62 nM. Notably, it demonstrated a sensitivity of 0.4038 μA μM^-1 cm^-2. The constructed sensor demonstrated noteworthy selectivity, stability, and repeatability. To assess the practicality of RIS, its performance was monitored in the tablet sample, resulting in satisfactory recoveries.