Determination and Correlation of Solubility of N-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K

Xiaoyu Cao; Yan Wang; Jianxing Lu; Qian Zhang; Tao Yuan; Shichao Du; Fumin Xue

doi:10.1021/acsomega.3c04044

Determination and Correlation of Solubility of N-Acetylglucosamine in Four Aqueous Binary Solvents from 283.15 to 323.15 K

ACS Omega. 2023 Dec 4;8(50):47463-47471. doi: 10.1021/acsomega.3c04044. eCollection 2023 Dec 19.

Authors

Xiaoyu Cao¹, Yan Wang¹, Jianxing Lu², Qian Zhang², Tao Yuan², Shichao Du¹, Fumin Xue¹

Affiliations

¹ School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, P.R. China.
² Shandong Runde Biotechnology Co.,Ltd., Taian 271000, P.R. China.

Abstract

N-Acetylglucosamine (NAG) is a significant novel functional monosaccharide with a wide range of potential applications, such as in the medical and cosmetic fields. A gravimetric technique was used to assess the solubility of NAG in water, methanol, N,N-dimethylformamide, water + methanol, water + n-propanol, water + N,N-dimethylformamide, and water + acetonitrile at temperatures ranging from 283.15 to 323.15 K. The outcomes of the experiment demonstrated that the temperature and water content were positively correlated with the solubility of NAG in four experimental binary solvents. The order of solubility in the four aqueous solvent mixtures is water + DMF > water + methanol > water + n-propanol > water + acetonitrile. The solubility data was well correlated using the modified Apelblat model, the CNIBS/R-K model, and the Apelblat-Jouyban-Acree model. Experimental data from NAG will help guide the design of cooling and dissolution in crystallization processes.