GABA storage and release from direct pathway neurons account for the enhanced short-duration response of L-dopa in Parkinson's disease

Haruo Nishijima; Masahiko Tomiyama

doi:10.1016/j.jns.2023.122844

GABA storage and release from direct pathway neurons account for the enhanced short-duration response of L-dopa in Parkinson's disease

J Neurol Sci. 2024 Jan 15:456:122844. doi: 10.1016/j.jns.2023.122844. Epub 2023 Dec 18.

Authors

Haruo Nishijima¹, Masahiko Tomiyama²

Affiliations

¹ Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan; Department of Neurology, Hirosaki University Hospital, Hirosaki City, Aomori, Japan. Electronic address: haruonishijima@gmail.com.
² Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan.

PMID: 38142158
DOI: 10.1016/j.jns.2023.122844

No abstract available

Keywords: L-dopa-induced dyskinesia; Motor fluctuation; Substantia nigra pars reticulata; The internal segment of the globus pallidus; Wearing OFF.

Publication types

Letter

MeSH terms

Dopamine / metabolism
Globus Pallidus / physiology
Humans
Levodopa* / therapeutic use
Neurons / metabolism
Oxidopamine / metabolism
Parkinson Disease* / drug therapy
Parkinson Disease* / metabolism
Substantia Nigra / metabolism
gamma-Aminobutyric Acid

Substances

Levodopa
gamma-Aminobutyric Acid
Dopamine
Oxidopamine