Interventional bronchoscopy in pediatric pulmonary tuberculosis

Expert Rev Respir Med. 2023 Dec;17(12):1159-1175. doi: 10.1080/17476348.2023.2299336. Epub 2023 Dec 28.

Abstract

Introduction: Lymphobronchial tuberculosis (TB) is common in children with primary TB and enlarged lymph nodes can cause airway compression of the large airways. If not treated correctly, airway compression can result in persistent and permanent parenchymal pathology, as well as irreversible lung destruction. Bronchoscopy was originally used to collect diagnostic samples; however, its role has evolved, and it is now used as an interventional tool in the diagnosis and management of complicated airway disease. Endoscopic treatment guidelines for children with TB are scarce.

Areas covered: The role of interventional bronchoscopy in the diagnosis and management of complicated pulmonary TB will be discussed. This review will provide practical insights into how and when to perform interventional procedures in children with complicated TB for both diagnostic and therapeutic purposes. This discussion incorporates current scientific evidence and refers to adult literature, as some of the interventions have only been done in adults but may have a role in children. Limitations and future perspectives will be examined.

Expert opinion: Pediatric pulmonary TB lends itself to endoscopic interventions as it is a disease with a good outcome if treated correctly. However, interventions must be limited to safeguard the parenchyma and prevent permanent damage.

Keywords: Flexible bronchoscopy; Xpert MTB/RIF; interventional bronchoscopy; pulmonary tuberculosis; rigid bronchoscopy.

Publication types

  • Review

MeSH terms

  • Adult
  • Bronchoscopy / adverse effects
  • Bronchoscopy / methods
  • Child
  • Humans
  • Lymphadenopathy*
  • Mycobacterium tuberculosis*
  • Sensitivity and Specificity
  • Sputum
  • Tuberculosis*
  • Tuberculosis, Pulmonary* / diagnosis
  • Tuberculosis, Pulmonary* / therapy