Interaction between Selected Adipokines and Musculoskeletal and Cardiovascular Systems: A Review of Current Knowledge

Int J Mol Sci. 2023 Dec 9;24(24):17287. doi: 10.3390/ijms242417287.

Abstract

Adipokines are substances secreted by adipose tissue that are receiving increasing attention. The approach to adipose tissue has changed in recent years, and it is no longer looked at as just a storage organ but its secretion and how it influences systems in the human body are also looked at. The role of adipokine seems crucial in developing future therapies for pathologies of selected systems. In this study, we look at selected adipokines, leptin, adiponectin, chemerin, resistin, omentin-1, nesfatin, irisin-1, visfatin, apelin, vaspin, heparin-binding EGF-like growth factor (HB-EGF), and TGF-β2, and how they affect systems in the human body related to physical activity such as the musculoskeletal and cardiovascular systems.

Keywords: adipokines; adiponectin; adipose tissue; leptin; physical activity.

Publication types

  • Review

MeSH terms

  • Adipokines* / metabolism
  • Adiponectin / metabolism
  • Adipose Tissue / metabolism
  • Cardiovascular System* / metabolism
  • Humans
  • Leptin / metabolism
  • Resistin / metabolism

Substances

  • Adipokines
  • Leptin
  • Resistin
  • Adiponectin

Grants and funding

This research received no external funding.