UVR and RPE - The Good, the Bad and the degenerate Macula

Graham Anderson; Shyamanga Borooah; Roly Megaw; Pierre Bagnaninchi; Richard Weller; Andrew McLeod FRSB; Baljean Dhillon

doi:10.1016/j.preteyeres.2023.101233

UVR and RPE - The Good, the Bad and the degenerate Macula

Prog Retin Eye Res. 2023 Dec 20:100:101233. doi: 10.1016/j.preteyeres.2023.101233. Online ahead of print.

Authors

Graham Anderson¹, Shyamanga Borooah², Roly Megaw³, Pierre Bagnaninchi⁴, Richard Weller⁵, Andrew McLeod FRSB⁶, Baljean Dhillon⁷

Affiliations

¹ Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, EH16 4UU, UK.
² Viterbi Family Department of Ophthalmology, Shiley Eye Institute, UC San Diego, CA, 92093-0946, USA.
³ Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, EH4 2XU, UK; Department of Clinical Ophthalmology, National Health Service Scotland, Edinburgh, EH3 9HA, UK.
⁴ Centre for Regenerative Medicine, University of Edinburgh, Edinburgh BioQuarter, EH16 4UU, UK; Robert O Curle Eyelab, Instute for Regeneration and Repair, Edinburgh BioQuarter, 4-5 Little France Drive, Edinburgh, EH16 4UU, UK.
⁵ Centre for Inflammation Research, University of Edinburgh, Edinburgh BioQuarter, EH16 4TJ, UK.
⁶ School of GeoSciences, University of Edinburgh, Crew Building, King's Buildings, EH9 3FF, UK.
⁷ Department of Clinical Ophthalmology, National Health Service Scotland, Edinburgh, EH3 9HA, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh BioQuarter, EH16 4SB, UK; Robert O Curle Eyelab, Instute for Regeneration and Repair, Edinburgh BioQuarter, 4-5 Little France Drive, Edinburgh, EH16 4UU, UK. Electronic address: baljean.dhillon@ed.ac.uk.

PMID: 38135244
DOI: 10.1016/j.preteyeres.2023.101233

Abstract

Ultraviolet Radiation (UVR) has a well-established causative influence within the aetiology of conditions of the skin and the anterior segment of the eye. However, a grounded assessment of the role of UVR within conditions of the retina has been hampered by a historical lack of quantitative, and spectrally resolved, assessment of how UVR impacts upon the retina in terms congruent with contemporary theories of ageing. In this review, we sought to summarise the key findings of research investigating the connection between UVR exposure in retinal cytopathology while identifying necessary avenues for future research which can deliver a deeper understanding of UVR's place within the retinal risk landscape.

Publication types

Review