Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia

Christine Tedijanto; Solomon Aragie; Sarah Gwyn; Dionna M Wittberg; Taye Zeru; Zerihun Tadesse; Ambahun Chernet; Isabel J B Thompson; Scott D Nash; Thomas M Lietman; Diana L Martin; Jeremy D Keenan; Benjamin F Arnold

doi:10.1093/infdis/jiad602

Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia

J Infect Dis. 2023 Dec 22:jiad602. doi: 10.1093/infdis/jiad602. Online ahead of print.

Authors

Christine Tedijanto¹, Solomon Aragie², Sarah Gwyn³, Dionna M Wittberg¹, Taye Zeru⁴, Zerihun Tadesse², Ambahun Chernet², Isabel J B Thompson¹, Scott D Nash⁵, Thomas M Lietman^{1

6

7}, Diana L Martin³, Jeremy D Keenan^{1

6}, Benjamin F Arnold^{1

6}

Affiliations

¹ Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA.
² The Carter Center Ethiopia, Addis Ababa, Ethiopia.
³ Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
⁴ Amhara Public Health Institute, Bahir Dar, Ethiopia.
⁵ The Carter Center, Atlanta, GA, USA.
⁶ Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
⁷ Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.

PMID: 38134305
DOI: 10.1093/infdis/jiad602

Abstract

Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.

Keywords: Chlamydia trachomatis; Ethiopia; IgG; antibody; seroepidemiology; trachoma.