Modeling elucidates context dependence in adipose regulation

Cameron D Vasquez; John G Albeck

doi:10.1016/j.cels.2023.11.002

Modeling elucidates context dependence in adipose regulation

Cell Syst. 2023 Dec 20;14(12):1021-1023. doi: 10.1016/j.cels.2023.11.002.

Authors

Cameron D Vasquez¹, John G Albeck²

Affiliations

¹ Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
² Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA. Electronic address: jgalbeck@ucdavis.edu.

PMID: 38128481
DOI: 10.1016/j.cels.2023.11.002

Abstract

Single-cell data and computational simulations reveal the dynamics of the transcription factors HIF1α and PPARγ during adipocyte differentiation and maturation. Modeling feedback within this network predicts a HIF1α-mediated choice between lipid accumulation and incomplete differentiation. In vitro experiments support this model, with implications for adipose dynamics in metabolic disorders involving hypoxia.

Publication types

Comment

MeSH terms

Adipocytes* / metabolism
Cell Differentiation
Diet, High-Fat
Humans
Obesity* / metabolism
Transcription Factors / metabolism

Substances

Transcription Factors

Grants and funding

R25 GM116690/GM/NIGMS NIH HHS/United States