Productive infection of primary human hepatocytes with SARS-CoV-2 induces antiviral and proinflammatory responses

Gut. 2023 Dec 12:gutjnl-2023-330961. doi: 10.1136/gutjnl-2023-330961. Online ahead of print.

Natalie Heinen¹, Rajendra Khanal^{2

3}, Saskia Westhoven¹, Mara Klöhn¹, Simon T Herrmann¹, Maike Herrmann⁴, Tran Tuoc⁵, Pauline Antonie Ulmke⁵, Hoang Duy Nguyen⁵, Huu Phuc Nguyen⁵, Eike Steinmann^{1

6}, Daniel Todt^{1

7}, Richard J P Brown^{8

4}, Amar Deep Sharma^{9

3}, Stephanie Pfaender⁸

¹ Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
² Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.
³ Research Group RNA Therapeutics & Liver Regeneration, REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Hannover Medical School, Hannover, Germany.
⁴ Division of Veterinary Medicine, Paul-Ehrlich-Institute, Langen, Germany.
⁵ Department of Human Genetics, Ruhr University Bochum, Bochum, Germany.
⁶ German Centre for Infection Research (DZIF), External Partner Site, Bochum, Germany, Bochum, Germany.
⁷ European Virus Bioinformatics Center (EVBC), Jena, Germany.
⁸ Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.
⁹ Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany stephanie.pfaender@rub.de sharma.amar@mh-hannover.de richard.brown@ruhr-uni-bochum.de.

No abstract available

Keywords: COVID-19; CYTOKINES; HEPATOCYTE; LIVER.

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