Precision-cut lung slices as an ex vivo model to study Pneumocystis murina survival and antimicrobial susceptibility

mBio. 2024 Jan 16;15(1):e0146423. doi: 10.1128/mbio.01464-23. Epub 2023 Dec 20.

Abstract

Our study reveals the potential of precision-cut lung slices as an ex vivo platform to study the growth/survival of Pneumocystis spp. that can facilitate the development of new anti-fungal drugs.

Keywords: PCLS; Pneumocystis murina; Pneumocystis pneumonia.

MeSH terms

  • Anti-Infective Agents*
  • Lung / microbiology
  • Pneumocystis*
  • Pneumonia, Pneumocystis* / microbiology

Substances

  • Anti-Infective Agents

Supplementary concepts

  • Pneumocystis murina