The emerging roles of protein arginine methyltransferases in antiviral innate immune signaling pathways

Hui Nie; Qingchao Li; Wei Pan

doi:10.3389/fmicb.2023.1322929

The emerging roles of protein arginine methyltransferases in antiviral innate immune signaling pathways

Front Microbiol. 2023 Dec 5:14:1322929. doi: 10.3389/fmicb.2023.1322929. eCollection 2023.

Authors

Hui Nie^#¹, Qingchao Li^#¹, Wei Pan¹

Affiliation

¹ Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Sciences, Shandong Normal University, Jinan, China.

^# Contributed equally.

Abstract

The Protein Arginine Methyltransferases (PRMTs) family is involved in various biological processes, including gene transcription, pre-mRNA splicing, mRNA translation, and protein stability. Recently, mounting evidence has shown that PRMTs also play critical roles in regulating the host antiviral immune response, either in an enzymatic activity dependent or independent manner. This review aims to provide an overview of the recent findings regarding the function and regulatory mechanisms of PRMTs in the antiviral response. These findings have the potential to aid in the discovery and design of novel therapeutic strategies for viral infections.

Keywords: arginine methylation; innate immunity; post-translational modification; protein arginine methyltransferases; viral infection.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by National Natural Science Foundation of China, grant number 31902257.