Increased syphilis testing and detection of late latent syphilis among women after switching from risk-based to opt-out testing strategy in an urban Australian sexual health clinic: a retrospective observational study

Palak Gupta; Christopher K Fairley; Marcus Y Chen; Catriona S Bradshaw; Glenda Fehler; Erica L Plummer; Lenka A Vodstrcil; Julien Tran; Ei T Aung; Eric P F Chow

doi:10.1016/j.lanwpc.2023.100875

Increased syphilis testing and detection of late latent syphilis among women after switching from risk-based to opt-out testing strategy in an urban Australian sexual health clinic: a retrospective observational study

Lancet Reg Health West Pac. 2023 Aug 7:40:100875. doi: 10.1016/j.lanwpc.2023.100875. eCollection 2023 Nov.

Authors

Palak Gupta^{1

2}, Christopher K Fairley^{1

2}, Marcus Y Chen^{1

2}, Catriona S Bradshaw^{1

2

3}, Glenda Fehler¹, Erica L Plummer^{1

2}, Lenka A Vodstrcil^{1

2

3}, Julien Tran^{1

2}, Ei T Aung^{1

2}, Eric P F Chow^{1

2

3}

Affiliations

¹ Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
² Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
³ Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Abstract

Background: The Melbourne Sexual Health Centre (MSHC) implemented an opt-out syphilis test for women in December 2017. We aimed to examine the differences in syphilis testing uptake and confirmed syphilis cases among women after switching from risk-based to opt-out testing strategies.

Methods: This was a retrospective study examining all women attending the MSHC for the first time in periods of risk-based testing (2015-2017) and opt-out testing (2018-2020). We calculated the proportion of women who tested for syphilis and the proportion of women with confirmed syphilis in each period. A chi-square test was performed to determine the differences in proportion between the risk-based testing and opt-out periods.

Findings: A total of 27,481 women (i.e. 13,059 in the risk-based testing period and 14,422 in the opt-out period) were included in the final analysis, and the mean age was 26.8 years (standard deviation = 6.9). The proportion of women who were tested for syphilis at their first consultation increased from 52.8% (6890/13,059) in the risk-based testing period to 67.4% (9725/14,422) in the opt-out period (p < 0.0001). Syphilis positivity did not differ between the two periods (0.48% [33/6890] vs 0.71% [69/9725], p = 0.061) but late latent causes increased from 36.4% [12/33] to 60.9% [42/69] (p = 0.033).

Interpretation: The opt-out testing strategy increased syphilis testing among women with increased detection of asymptomatic late latent syphilis. The opt-out syphilis testing strategy is beneficial in sexual health services. Health education and awareness may be required to improve syphilis testing uptake.

Funding: National Health and Medical Research Council.

Keywords: Screening; Sexually transmitted disease; Sexually transmitted infection; Syphilis; Women's health.