Cardio-renal-metabolic disease in primary care setting

Diabetes Metab Res Rev. 2024 Mar;40(3):e3755. doi: 10.1002/dmrr.3755. Epub 2023 Dec 19.

Abstract

In the primary care setting providers have more tools available than ever before to impact positively obesity, diabetes, and their complications, such as renal and cardiac diseases. It is important to recognise what is available for treatment taking into account diabetes heterogeneity. For those who develop type 2 diabetes (T2DM), effective treatments are available that for the first time have shown a benefit in reducing mortality and macrovascular complications, in addition to the well-established benefits of glucose control in reducing microvascular complications. Some of the newer medications for treating hyperglycaemia have also a positive impact in reducing heart failure (HF). Technological advances have also contributed to improving the quality of care in patients with diabetes. The use of technology, such as continuous glucose monitoring systems (CGM), has improved significantly glucose and glycated haemoglobin A1c (HbA1c) values, while limiting the frequency of hypoglycaemia. Other technological support derives from the use of predictive algorithms that need to be refined to help predict those subjects who are at great risk of developing the disease and/or its complications, or who may require care by other specialists. In this review we also provide recommendations for the optimal use of the new medications; sodium-glucose co-transporter-2 inhibitors (SGLT2i) and Glucagon-like peptide-receptor agonists 1 (GLP1RA) in the primary care setting considering the relevance of these drugs for the management of T2DM also in its early stage.

Keywords: CVOTs; chronic kidney disease; heart failure; obesity; technology; type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Blood Glucose
  • Blood Glucose Self-Monitoring
  • Cardiovascular Diseases* / complications
  • Diabetes Mellitus, Type 2* / complications
  • Glucagon-Like Peptide 1 / therapeutic use
  • Glucagon-Like Peptide-1 Receptor
  • Heart Diseases* / complications
  • Heart Diseases* / drug therapy
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Primary Health Care
  • Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

  • Hypoglycemic Agents
  • Blood Glucose
  • Sodium-Glucose Transporter 2 Inhibitors
  • Glucagon-Like Peptide 1
  • Glucagon-Like Peptide-1 Receptor