Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders

Zahra Yaghoobi; Shahrzad Sadat Seyed Bagher Nazeri; Amir Asadi; Ehsan Derafsh; Abdolkarim Talebi Taheri; Zeinab Tamtaji; Ehsan Dadgostar; Fatemeh Rahmati-Dehkordi; Michael Aschner; Hamed Mirzaei; Omid Reza Tamtaji; Fatemeh Nabavizadeh

doi:10.1007/s11064-023-04067-8

Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders

Neurochem Res. 2024 Mar;49(3):583-596. doi: 10.1007/s11064-023-04067-8. Epub 2023 Dec 19.

Authors

Zahra Yaghoobi^{1

2}, Shahrzad Sadat Seyed Bagher Nazeri³, Amir Asadi⁴, Ehsan Derafsh⁵, Abdolkarim Talebi Taheri⁶, Zeinab Tamtaji⁷, Ehsan Dadgostar^{8

9}, Fatemeh Rahmati-Dehkordi^{1

2}, Michael Aschner¹⁰, Hamed Mirzaei¹¹, Omid Reza Tamtaji^{12

13}, Fatemeh Nabavizadeh^{14

15}

Affiliations

¹ Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I.R. of Iran.
² Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. of Iran.
³ School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Psychiatry and Behavioral Sciences Research Center, School of Medicine, Addiction Institute, and Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran.
⁵ Windsor University School of Medicine, Cayon, St Kitts and Nevis.
⁶ Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. of Iran.
⁸ Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran.
⁹ Student Research Committee, Isfahan University of Medical Sciences, Isfahan, I.R. of Iran.
¹⁰ Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
¹¹ Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. of Iran. h.mirzaei2002@gmail.com.
¹² Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I.R. of Iran. Tamtaji.or@gmail.com.
¹³ Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. of Iran. Tamtaji.or@gmail.com.
¹⁴ Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, I.R. of Iran. nabavizadeh@tums.ac.ir.
¹⁵ Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, I.R. of Iran. nabavizadeh@tums.ac.ir.

PMID: 38114727
DOI: 10.1007/s11064-023-04067-8

Abstract

Neurological disorders are a major group of non-communicable diseases affecting quality of life. Non-Coding RNAs (ncRNAs) have an important role in the etiology of neurological disorders. In studies on the genesis of neurological diseases, aquaporin 4 (AQP4) expression and activity have both been linked to ncRNAs. The upregulation or downregulation of several ncRNAs leads to neurological disorder progression by targeting AQP4. The role of ncRNAs and AQP4 in neurological disorders is discussed in this review.

Keywords: Aquaporin-4; Long non-coding RNA; Neurological disorders; Non-coding RNAs; microRNA.

Publication types

Review

MeSH terms

Aquaporin 4 / genetics
Aquaporin 4 / metabolism
Down-Regulation
Humans
MicroRNAs*
Nervous System Diseases* / genetics
Quality of Life
RNA, Untranslated / metabolism

Substances

Aquaporin 4
RNA, Untranslated
MicroRNAs