Zn(II) Coordination Polymer: Luminescence Sensing for Fe3+ Ion and Used as Metal Gel Particles Against Lung Cancer

Wen Dong; Rong Xie; Nan Yang; Shengming Liu

doi:10.1007/s10895-023-03547-y

Zn(II) Coordination Polymer: Luminescence Sensing for Fe³⁺ Ion and Used as Metal Gel Particles Against Lung Cancer

J Fluoresc. 2023 Dec 19. doi: 10.1007/s10895-023-03547-y. Online ahead of print.

Authors

Wen Dong^{1

2}, Rong Xie³, Nan Yang², Shengming Liu⁴

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
² Department of Respiratory Medicine, Hainan Cancer Hospital, Haikou, Hainan, China.
³ Department of the Traditional Chinese Medicine, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
⁴ Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China. sm_liu2023@126.com.

PMID: 38112989
DOI: 10.1007/s10895-023-03547-y

Abstract

Presented here is a new Zn(II) coordination polymer, namely [Zn₂(L)₂(bpe)]_n (1, H₂L = 4-({2-[(4-carboxyphenoxy)methyl]phenyl}methoxy)benzoic acid, bpe = 1,2-bis(4-pyridinyl)ethane), which has been hydrothermally synthesized via the mixed-ligand strategy. Moreover, compound 1 emits intense luminescence at room temperature, and can be used as a luminescent sensor for the detection of Fe³⁺ in water solution with high selectivity and sensitivity. As representatives of natural polysaccharides, hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) have good biocompatibility. A new type of HA/CMCS gel particles loaded with Paclitaxel drug metal-organic framework was prepared by chemical synthesis method and its micromorphology was studied. Finally, biological experiments were conducted to evaluate the new system's effect on the activity of human lung cancer cells.

Keywords: Hydrogels; Luminescence sensing; Zn(II) compound.