Potentials of ionic liquids to overcome physical and biological barriers

Elfa Beaven; Raj Kumar; Jeong Man An; Hannia Mendoza; Sabuj Chandra Sutradhar; Wonho Choi; Mahesh Narayan; Yong-Kyu Lee; Md Nurunnabi

doi:10.1016/j.addr.2023.115157

Potentials of ionic liquids to overcome physical and biological barriers

Adv Drug Deliv Rev. 2024 Jan:204:115157. doi: 10.1016/j.addr.2023.115157. Epub 2023 Dec 15.

Authors

Elfa Beaven¹, Raj Kumar¹, Jeong Man An², Hannia Mendoza³, Sabuj Chandra Sutradhar⁴, Wonho Choi⁴, Mahesh Narayan³, Yong-Kyu Lee⁵, Md Nurunnabi⁶

Affiliations

¹ Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States; Biomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States.
² Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea.
³ Department of Chemistry and Biochemistry, College of Science, University of Texas at El Paso, El Paso, TX 79968, United States.
⁴ 4D Convergence Technology Institute, Korea National University of Transportation, Jungpyeong 27909, Republic of Korea.
⁵ Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Department of Chemical and Biological Engineering, College of Engineering, Korea National University of Transportation, Chungju 380-702, Republic of Korea; 4D Convergence Technology Institute, Korea National University of Transportation, Jungpyeong 27909, Republic of Korea. Electronic address: leeyk@ut.ac.kr.
⁶ Department of Pharmaceutical Sciences, School of Pharmacy, University of Texas at El Paso, El Paso, TX 79902, United States; Biomedical Engineering Program, College of Engineering, University of Texas at El Paso, El Paso, TX 79968, United States; Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, United States. Electronic address: mnurunnabi@utep.edu.

Abstract

Over the last decades, ionic liquids (IL) have shown great potential in non-invasive delivery starting from synthetic small molecules to biological large molecules. ILs are emerging as a particular class of drug delivery systems due to their unique physiochemical properties, simple surface modification, and functionalization. These features of IL help achieve specific design principles that are essential for a non-invasive drug delivery system. In this review, we have discussed IL and their applications in non-invasive drug delivery systems. We evaluated state-of-the-art development and advances of IL aiming to mitigate the biological and physical barriers to improve transdermal and oral delivery, summarized in this review. We also provided an overview of the various factors determining the systemic transportation of IL-based formulation. Additionally, we have emphasized how the ILs facilitate the transportation of therapeutic molecules by overcoming biological barriers.

Keywords: Biological barrier; Ionic liquid; Local delivery; Noninvasive delivery; Systemic delivery.

Publication types

Review

MeSH terms

Administration, Cutaneous
Drug Delivery Systems
Humans
Ionic Liquids* / chemistry

Substances

Ionic Liquids

Grants and funding

R03 OD032624/OD/NIH HHS/United States