The role of snapin in regulation of brain homeostasis

Jiawen Li; Xinqi Huang; Yumei An; Xueshi Chen; Yiyang Chen; Mingyuan Xu; Haiyan Shan; Mingyang Zhang

doi:10.4103/1673-5374.389364

The role of snapin in regulation of brain homeostasis

Neural Regen Res. 2024 Aug 1;19(8):1696-1701. doi: 10.4103/1673-5374.389364. Epub 2023 Nov 8.

Authors

Jiawen Li^{1

2}, Xinqi Huang², Yumei An², Xueshi Chen², Yiyang Chen², Mingyuan Xu², Haiyan Shan³, Mingyang Zhang^{1

2}

Affiliations

¹ Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice, China (Academy of Forensic Science), Shanghai, China.
² Institute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu Province, China.
³ Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China.

Abstract

Brain homeostasis refers to the normal working state of the brain in a certain period, which is important for overall health and normal life activities. Currently, there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance. Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses. Recently, many researchers have reported the association between snapin and neurologic and psychiatric disorders, demonstrating that snapin can improve brain homeostasis. Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae. This article aims to explore the role of snapin in restoring brain homeostasis after injury or diseases, highlighting its significance in maintaining brain homeostasis and treating brain diseases. Additionally, it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections, with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

Grants and funding

Funding:This work was supported by the National Natural Science Foundation of China, Nos. 82071382 (to MZ), 81601306 (to HS); the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (to MZ); Jiangsu 333 High Level Talent Training Project (2022) (to HS); the Jiangsu Maternal and Child Health Research Key Project (F202013) (to HS); Jiangsu Talent Youth Medical Program, No. QNRC2016245 (to HS); Shanghai Key Lab of Forensic Medicine, No. KF2102 (to MZ); Suzhou Science and Technology Development Project, No. SYS2020089 (to MZ); the Fifth Batch of Gusu District Health Talent Training Project, No. GSWS2019060 (to HS).