8 R-methoxy-9 R-hydroxyl-fumitremorgin C, a new diketopiperazine alkaloid from Haima cold seep-derived fungus Aspergillus fumigatus CYH-5

Yi-Hao Che; Jun-Feng Wang; Xue-Feng Shi; Wen-Ping Ding; Zhi-Hui Xiao; Jia-Min Wu; Fa-Zuo Wang; Si Zhang

doi:10.1080/14786419.2023.2294483

8 R-methoxy-9 R-hydroxyl-fumitremorgin C, a new diketopiperazine alkaloid from Haima cold seep-derived fungus Aspergillus fumigatus CYH-5

Nat Prod Res. 2023 Dec 15:1-6. doi: 10.1080/14786419.2023.2294483. Online ahead of print.

Authors

Yi-Hao Che^{1

2}, Jun-Feng Wang¹, Xue-Feng Shi¹, Wen-Ping Ding¹, Zhi-Hui Xiao¹, Jia-Min Wu^{1

2}, Fa-Zuo Wang¹, Si Zhang¹

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
² University of Chinese Academy of Sciences, Beijing, China.

PMID: 38099373
DOI: 10.1080/14786419.2023.2294483

Abstract

One novel diketopiperazine derivative 8R-methoxy-9R-hydroxyl-fumitremorgin C (1), together with twelve known compounds, was separated from the fungus Aspergillus fumigatus CYH-5 collected from Haima cold seep. The structures of the compounds were identified by NMR, MS, optical rotation, hydrolysis reaction and comparing with literatures. Among them, compounds 10 and 11 exhibited inhibitory effect against bacteria. Compound 11 showed inhibitory activity on α-glucosidase and compound 8 displayed acetylcholinesterase (AchE) inhibitory activity.

Keywords: Cold seep; activity; fungi; secondary metabolite.