Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

María M Soto Perezchica; Alma L Guerrero Barrera; Francisco J Avelar Gonzalez; Teodulo Quezada Tristan; Osvaldo Macias Marin

doi:10.3389/fvets.2023.1276712

Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

Front Vet Sci. 2023 Nov 30:10:1276712. doi: 10.3389/fvets.2023.1276712. eCollection 2023.

Authors

María M Soto Perezchica¹, Alma L Guerrero Barrera¹, Francisco J Avelar Gonzalez², Teodulo Quezada Tristan³, Osvaldo Macias Marin¹

Affiliations

¹ Laboratorio de Biología Celular y Tisular, Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.
² Laboratorio de Estudios Ambientales, Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.
³ Departamento de Ciencias Veterinaria, Centro de Ciencias Agropecuarias, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.

Abstract

Actinobacillus pleuropneumoniae (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.

Keywords: Actinobacillus pleuropneumoniae; bacterial envelope; biofilm; membrane proteins; proteome; vaccine.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financed through the support of the CONACyT scholarship (615420), through the support of PIB19-3 Host-pathogen relationship between bacteria and eukaryotic cells, and Resources of the Doctorate in Biological Sciences of the Autonomous University of Aguascalientes, Mexico.