Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy
Signal Transduct Target Ther
.
2023 Dec 15;8(1):454.
doi: 10.1038/s41392-023-01715-x.
Authors
Lei Yu
#
1
,
Pengcheng Zhao
#
1
,
Yaoliang Sun
#
2
,
Zening Zheng
#
1
,
Wenhao Du
2
,
Lishan Zhang
2
,
Yaxu Li
1
,
Longyan Xie
1
,
Shilin Xu
3
,
Ping Wang
4
Affiliations
1
Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
2
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
3
Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. slxu@simm.ac.cn.
4
Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. wangp@tongji.edu.cn.
#
Contributed equally.
PMID:
38097557
PMCID:
PMC10721786
DOI:
10.1038/s41392-023-01715-x
No abstract available
Publication types
Letter
MeSH terms
Aminoacyltransferases* / metabolism
Nitriles
Substances
glutaminyl-peptide cyclotransferase
benzonitrile
Aminoacyltransferases
Nitriles
Grants and funding
82341028/National Natural Science Foundation of China (National Science Foundation of China)
2220708/National Natural Science Foundation of China (National Science Foundation of China)
82103973/National Natural Science Foundation of China (National Science Foundation of China)