Lanostane triterpenoids from the fruiting bodies of Ganoderma amboinense

Li Yang; Guan-Hai Dong; Qing-Yun Ma; Qing-Yi Xie; Jiao-Cen Guo; Jia-Ju Lu; You-Gen Wu; Hao-Fu Dai; You-Xing Zhao

doi:10.1016/j.phytochem.2023.113952

Lanostane triterpenoids from the fruiting bodies of Ganoderma amboinense

Phytochemistry. 2024 Feb:218:113952. doi: 10.1016/j.phytochem.2023.113952. Epub 2023 Dec 12.

Authors

Li Yang¹, Guan-Hai Dong¹, Qing-Yun Ma¹, Qing-Yi Xie¹, Jiao-Cen Guo¹, Jia-Ju Lu², You-Gen Wu³, Hao-Fu Dai⁴, You-Xing Zhao⁵

Affiliations

¹ Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
² Guizhou Institute of Subtropical Crops, Xingyi, Guizhou, 562400, China.
³ Sanya Nanfan Research Institute, Hainan University, Sanya, 572025, China. Electronic address: wygeng2003@163.com.
⁴ Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. Electronic address: daihaofu@itbb.org.cn.
⁵ Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. Electronic address: zhaoyouxing@itbb.org.cn.

PMID: 38096963
DOI: 10.1016/j.phytochem.2023.113952

Abstract

Lanostane-type triterpenoids are the main characteristic constituents in Ganoderma mushrooms. Phytochemical analysis on the ethanol extract of the fruiting bodies of Ganoderma amboinense led to isolation and identification of twelve previously undescribed lanostane triterpenoids (1-12). Their chemical structures were determined by HR-ESI-MS, IR, and NMR spectroscopic analysis, NMR calculation, as well as X-ray crystallography. All isolates were evaluated for the α-glucosidase inhibitory and anti-inflammatory activities. Compounds 1, 5, 6, and 11 showed significant α-glucosidase inhibitory activity with IC₅₀ values ranging from 33.5 μM to 96.0 μM. Moreover, compound 12 showed anti-inflammatory activity with IC₅₀ value of 21.7 ± 2.1 μM.

Keywords: Anti-inflammatory activity; Ganoderma amboinense. lanostane triterpenoid; α-glucosidase inhibitory activity.

MeSH terms

Anti-Inflammatory Agents
Fruiting Bodies, Fungal / chemistry
Ganoderma* / chemistry
Molecular Structure
Steroids / analysis
Triterpenes* / chemistry
Triterpenes* / pharmacology
alpha-Glucosidases

Substances

Triterpenes
alpha-Glucosidases
Steroids
Anti-Inflammatory Agents