Bacterial antigens unleash tumor-targeting immunity

Nina Boeck; Zlatko Trajanoski; Lorenzo Galluzzi

doi:10.1016/j.chom.2023.11.001

Bacterial antigens unleash tumor-targeting immunity

Cell Host Microbe. 2023 Dec 13;31(12):1945-1947. doi: 10.1016/j.chom.2023.11.001.

Authors

Nina Boeck¹, Zlatko Trajanoski², Lorenzo Galluzzi³

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.
² Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.
³ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.

Abstract

The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.

MeSH terms

Antigens, Bacterial
Colorectal Neoplasms* / microbiology
Epitopes
Gastrointestinal Microbiome* / physiology
Humans
Immunity

Substances

Antigens, Bacterial
Epitopes

Abstract

MeSH terms

Substances

Grants and funding