Evaluation of a minimal array of Treponema pallidum antigens as biomarkers for syphilis diagnosis, infection staging, and response to treatment

Austin M Haynes; Kelika A Konda; Emily Romeis; Janet Siebert; Silver K Vargas; Michael Reyes Diaz; Amber Phan; Carlos F Caceres; Lorenzo Giacani; Jeffrey D Klausner

doi:10.1128/spectrum.03466-23

Evaluation of a minimal array of Treponema pallidum antigens as biomarkers for syphilis diagnosis, infection staging, and response to treatment

Microbiol Spectr. 2024 Jan 11;12(1):e0346623. doi: 10.1128/spectrum.03466-23. Epub 2023 Dec 14.

Authors

Affiliations

¹ Department of Medicine, Division of Allergy and Infectious Diseases, Harborview Medical Center, University of Washington , Seattle, Washington, USA.
² Division of Infectious Disease, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California, USA.
³ Center for Interdisciplinary Studies in Sexuality, AIDS and Society, Universidad Peruana Cayetano Heredia , Lima, Peru.
⁴ CytoAnalytics , Denver, Colorado, USA.
⁵ Department of Global Health, Harborview Medical Center, University of Washington , Seattle, Washington, USA.
⁶ Keck School of Medicine, University of Southern California , Los Angeles, California, USA.

Abstract

This manuscript explores the host humoral response to selected antigens of the syphilis agent during infection to evaluate their potential use as diagnostic tests and markers for treatment.

Keywords: Treponema pallidum; protein array; serodiagnosis; staging; syphilis; treatment response.

MeSH terms

Antibodies, Bacterial
Antigens, Bacterial
Biomarkers
Humans
Syphilis* / diagnosis
Syphilis* / drug therapy
Treponema pallidum

Substances

Antigens, Bacterial
Biomarkers
Antibodies, Bacterial

Abstract

MeSH terms

Substances

Grants and funding