Repeat bidirectional double-balloon enteroscopy 1 year later may be proper in Peutz-Jeghers patients with difficult-to-reach polyps

Yohei Funayama; Kunihiko Oguro; Hirotsugu Sakamoto; Tomonori Yano; Jun Owada; Takuma Kobayashi; Yusuke Ono; Alan Kawarai Lefor; Hironori Yamamoto

doi:10.1055/a-2180-9442

Repeat bidirectional double-balloon enteroscopy 1 year later may be proper in Peutz-Jeghers patients with difficult-to-reach polyps

Endosc Int Open. 2023 Dec 12;11(12):E1110-E1115. doi: 10.1055/a-2180-9442. eCollection 2023 Dec.

Authors

Yohei Funayama¹, Kunihiko Oguro¹, Hirotsugu Sakamoto¹, Tomonori Yano¹, Jun Owada¹, Takuma Kobayashi¹, Yusuke Ono¹, Alan Kawarai Lefor², Hironori Yamamoto¹

Affiliations

¹ Department of Medicine, Division of Gastroenterology, Jichi Medical University, Shimotsuke, Japan.
² Department of Surgery, Jichi Medical University, Shimotsuke, Japan.

Abstract

Background and study aims Small-bowel polyps in patients with Peutz-Jeghers syndrome (PJS) are sometimes difficult to reach using double-balloon enteroscopy (DBE). However, they can induce intussusception, especially when ≧15 mm. This study aimed to review the outcomes of patients with such polyps. Patients and methods All patients with PJS with small-bowel polyps that bidirectional DBE failed to reach and were ≧5 mm as shown by DBE enterography at our institution from May 2006 to April 2022 were retrospectively evaluated. The endpoint was the earliest occurrence of symptomatic intussusception induced by the polyp, endoscopic removal by repeat DBE or intraoperative endoscopy, or the last medical record describing the patient's condition. Results This study included 27 polyps in 13 patients. All patients had extraluminal adhesions. None developed symptomatic intussusception, eight patients underwent endoscopic removal at repeat DBE without surgery, two patients underwent removal with intraoperative endoscopy, two patients were observed without polyp removal, and one patient had a polyp removed at repeat DBE and three unreachable polyps remained. Repeat DBE without surgery was able to remove 14 polyps (52%). Polyps ≧15 mm included 11 lesions in eight patients and were observed for a median of 14 months without symptomatic intussusception. Conclusions The difficult-to-reach polyps may have a low risk of immediate symptomatic intussusception, possibly due to limited bowel mobility by extraluminal adhesions, and the likelihood of reaching them at repeat DBE was substantial. Hence, repeat DBE 1 year later may be proper in such patients with PJS.

Keywords: Neoplasia; Small bowel endoscopy.

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