NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms

Cancer Cell. 2023 Dec 11;41(12):2014-2016. doi: 10.1016/j.ccell.2023.11.006.

Abstract

Neuroendocrine neoplasms are rare cancers with limited treatment options and preclinical models. In this issue of Cancer Cell, Dayton et al. establish a patient-derived tumor organoid biobank encompassing pulmonary low-grade neuroendocrine tumors (LNETs) and high-grade neuroendocrine carcinomas (LCNECs), identifying novel biomarker-dependent therapeutic vulnerabilities using niche perturbation and drug response assays.

Publication types

  • Comment

MeSH terms

  • Biological Specimen Banks
  • Carcinoma, Neuroendocrine* / drug therapy
  • Carcinoma, Neuroendocrine* / genetics
  • Humans
  • Lung Neoplasms* / pathology
  • Neuroendocrine Tumors* / drug therapy
  • Neuroendocrine Tumors* / genetics
  • Neuroendocrine Tumors* / pathology