Recent Advancement on the Indirect or Combined Alternative Thiocyanate Sources for the Construction of S-CN Bonds

Abstract

The process of thiocyanation is a notable chemical conversion owing to the extensive range of applications associated with thiocyanate compounds in the field of organic chemistry. In past centuries, the thiocyanation reaction incorporated metal thiocyanates or thiocyanate salts as sources of thiocyanate, which are environmentally detrimental and undesirable. In recent literature, there have been numerous instances where combined or indirect alternative sources of thiocyanate have been employed as agents for thiocyanation, showcasing their noteworthy applications. The present literature review focuses on elucidating the ramifications associated with the utilization of indirect or combined alternative sources of thiocyanate in various thiocyanation reactions.

Keywords: Thiocyanation reaction; electrophilic or radical indirect thiocyanates; methodologies; nucleophilic indirect thiocyanates; synthetic transformations.