Radio Frequency (RF) sensor is widely used to monitor physiological signals. Generally, RF sensor simulation is mostly done using a layered model, which sometimes cannot model the accurate properties in the real world. A voxel vascular structure-based mannequin-like arm electromagnetic model (VVS-MaM) is proposed to evaluate the RF sensor, which mainly gathers the real physiological signal. This model is built with high-precision Magnetic Resonance Imaging (MRI), and it can finish fast simulation while there is also a voxel-like part in it which means it has the advantages of both the layered model and the real human model. After modelling, both simulation and in-vivo experiments are designed to test this sensor. In the simulation, the simulated standard resonant frequency of the equivalent model is 1.8137 GHz, and the relative error of the VVS-MaM is 0.012 GHz, which is closer to the standard value than the layer model result of 0.049 GHz. Meanwhile, in the in-vivo experiments, an RF sensor based on a composite right/left-handed transmission line (CRLH-TL) and complementary split resonator rings (CSRRs) are fabricated, and the measurements from the real experiments are gathered and stored to compare with that of the simulation. The comparison shows that the relative error of the VVS-MaM (0.08804 GHz)is closer to the in-vivo measurements than that of the layer model (0.09891 GHz), which validates the performance of VVS-MaM.Clinical Relevance-Radio Frequency, magnetic resonance imaging, scattering parameter, composite right/left-handed, complementary split resonator ring.